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We’ve come to the last day of IAS 2023! The closing session this afternoon is a must, but there’s a full programme before that.
Coming up today
Convert to your time zone through the IAS 2023 programme.
07:30 AEST
Satellite sessions get underway.
09:00 AEST
Thumbi Ndung’u from the Africa Health Research Institute at the University of Kwazulu-Natal, South Africa, moderates the plenary session, “Understanding the HIV reservoir: New technologies and specific populations”. Ya-Chi Ho from Yale University, US, presents “New approaches to measuring the reservoir” and Asier Sáez-Cirión from Institut Pasteur, France, and author of the "Geneva Patient" study, presents “Understanding elite control to inform cure strategies”.
10:30 AEST
HPTN 084-01 and acceptability of CAB-LA in cisgender female adolescents in South Africa, Uganda and Zimbabwe is among presentations in a Track C late-breaker session. Also learn about findings from the WHO Global Clinical Platform for COVID-19 on high in-hospital mortality among people living with HIV, and more.
The latest advances in long-acting antiretroviral therapy and implementation of currently available treatment for people everywhere is the focus of a symposium at this time. A symposium on immune responses critical to viral control looks at how viruses evade the immune system and ways to enhance immune responses, such as vaccines, B cell engineering and gene therapies.
Community engagement with science is under the spotlight at a symposium that details trans people doing multi-country research and women living with HIV leading research in their communities. Emerging sexual cultures and social contexts is the focus of a symposium that also showcases innovative interventions and programmes that have been set up in challenging contexts.
Oral abstract sessions include “Beyond suppression: Improving the trajectory of co-morbidities in people with HIV” and “From silos to solutions: Embracing integration for better health outcomes”.
12:00 AEST
The final symposia and oral abstracts of IAS 2023 take place at this time.
A symposium on decolonizing HIV science explores the many ways that HIV science promotes production of biased knowledge and contributes to structural inequalities.
Another symposium at this time considers the latest advances in PEP, PrEP and vaccines for STIs and priorities for research and programmes to maximize benefit for those at greatest need.
The oral abstract session, “HIV prevention: Novel approaches and promising findings”, includes results of the HPTN 084 open-label extension. Other sessions explore transmission and novelties in vaccine design, meeting the needs of key populations, differentiated service delivery for PrEP, and barriers and solutions along the HIV care continuum.
13:30 AEST
At the final plenary session of IAS 2023, moderated by IAS Executive Director Birgit Poniatowski, lead rapporteurs report back on key conference highlights across its five tracks.
14:45 AEST
Please join us for the IAS 2023 closing session! Krista Adams, Deputy Mayor of Brisbane, and Honourable Shannon Fentiman, Queensland's Minister for Health, Mental Health and Ambulance Services and Minister for Women, address delegates. Michelle Tobin from the Positive Aboriginal Torres Strait Islander Network and Anwernekenhe National HIV Alliance, Australia, delivers the community address, and Local Chair Charles Gilks and International Chair Sharon Lewin offer closing remarks.
Expect a fascinating panel discussion, titled “Leadership, communication and science: A three-dimensional pandemic response?”, with Glenda Gray (South African Medical Research Council), James Chau (China-US Exchange Foundation and WHO Goodwill Ambassador, China), Anthony Fauci (formerly US National Institute of Allergy and Infectious Diseases), John N Nkengasong (US President’s Emergency Plan for AIDS Relief) and Gracia Violeta Ross Quiroga (World Council of Churches).
Yesterday
25 July recap
Key takeaways from yesterday are:
HIV, mpox and COVID-19: WHO’s 2022 global surveillance analysis shows that people living with HIV who acquired mpox were not more likely to be hospitalized unless they were immunosuppressed – and uncontrolled HIV might lead to disproportionate mpox morbidity. Health systems should therefore ensure that people living with HIV are aware of their status, linked to care, on effective ART and achieve viral suppression. Mpox testing can be an opportunity to do that.
A cross-track symposium explored what we have learnt from COVID-19 and mpox, including how to minimize the impacts of a pandemic in Africa.
Cure: A poster detailed a novel cure study examining potent, HIV-specific latency reversal through CRISPR activation delivered by lipid nanoparticles. Researchers hypothesized that mRNA-lipid nanoparticles (LNPs) could be used to advance CRISPR activation as a next-generation latency-reversing agent. Results showed that the novel LNP formulation was capable of delivering nucleic acid-based therapeutics to resting CD4+ T cells. The three-component dCas9-SAM CRISPR activation system could be co-encapsulated within one LNP and induce strong latency reversal in a cell line model for HIV latency.
A symposium on advances in gene delivery and engineering of T and B cells explored genetic delivery strategies that may lead to long-term expression and greater access to HIV sanctuary sites to suppress viral replication, potentially eliminate infected cells or render target cells resistant to infection.
Prevention: The plenary session, “The latest in HIV and STI prevention”, included presentations on implementation of doxycycline post-exposure prophylaxis for STIs and mAbs for prevention.
Tapping into technology: The COVID-19 response showed that technology can be used to improve healthcare delivery, as explored in “Innovations for equity”. We also heard how digital interventions are improving access to HIV prevention and testing services in low- and middle-income settings, facilitating achievement of the UNAIDS 95-95-95 targets.
Communities leading: Sexualized drug use is a growing concern in Asia-Pacific, but harm reduction, psychosocial support and peer-based services are limited. Criminalization, punishment and stigma towards people who use drugs are all barriers to accessing social services and healthcare. A symposium explored promising community-led responses to this complex intersectional issue.
Towards equity: Simplified regimens and point-of-care testing for children and adolescents to end the AIDS pandemic came under the spotlight in a presentation by Moherndran Archary (University of KwaZulu-Natal, African Health Research Institution, South Africa) at the plenary session, “Innovations for equity”. Yazdan Yazdanpanah (ANRS Emerging Infectious Diseases, France) presented on lessons from HIV on strengthening health systems for pandemic preparedness.
Brisbane turns red for IAS 2023
Yesterday, Brisbane's Victoria and Story bridges were lit up red for IAS 2023 to show solidarity with people living with and affected by HIV. Thanks to the Brisbane City Council and Brisbane Convention & Exhibition Centre for this show of support.
HIV unmuted - the IAS podcast
In this episode of HIV unmuted, the award-winning IAS podcast, we take a deep dive into the breaking science being released at IAS 2023, and explain why these breakthroughs are so important for people living with and affected by HIV.
Rapporteur summaries
The rapporteur summaries are your primary source for the highlights presented at IAS 2023. Thanks to the IAS 2023 team of experts, delegates can access daily recaps by each programme track. The rapporteur summaries will be available by 22:00 AEST each day here.
JIAS supplement just launched
Read the IAS 2023 Abstract Supplement now! You can access all oral abstracts, poster exhibitions and late breakers from IAS 2023 for free in the new JIAS Abstract Supplement.
Language matters
The IAS advocates for the use of language that is inclusive, anti-stigma and puts the person before their condition. For IAS 2023, we provided language guidelines to abstract submitters and invited speakers. We piloted software that screened thousands of submissions, flagged offensive words and provided alternatives to those words. As a result, not one of the abstracts submitted for IAS 2023 included “HIV-infected” to label people living with HIV. For more information click here.
IAS 2023 in pictures!
You will be able to find a selection of photographs from IAS 2023 here. We will keep updating this photo gallery with the best pictures throughout the conference and more photos will also be added one week after the conference finishes.
In the news
Stay safe, HIV still a threat Nation (Kenya)
IAS 2023: Commitment and Community in the Face of Uncertainty Positively Aware (United States)
Can we completely eliminate HIV? ABC (Australia)
Doravirine/islatravir just as effective as Biktarvy in previously untreated people NAM aidsmap (Country)
Statins reduce cardiovascular risk in people living with HIV, new global study finds STAT (Unites States)
Meet the IAS change makers
Each day, the Daily Digest follows the IAS change makers at IAS 2023: HIV researchers, advocates, healthcare providers and others we educate to drive an evidence-based HIV response that puts people first.
Today’s change maker is Philister Adhiambo, a community engagement lead at the Kenya Medical Research Institute/Centre for Global Research in Kisumu. She coordinates community involvement in HIV, paediatric and COVID-19 studies.
With expertise in HIV interventions and broadly neutralizing antibodies, she focuses on community mobilization and information dissemination to respond to diseases and promote innovative biologics. At IAS 2023, Philister is one of 22 change makers in the IAS Towards an HIV Cure programme.
Snapshots from IAS 2023
Official media partner coverage
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