In 2017, Noludwe Mabandlela, 40, was hospitalized with unexplained symptoms of a chronic fatigue and shortness of breath. After examination, her doctors in the township of Khayelitsha, Cape Town, diagnosed her with TB. She underwent a round of first-line treatment, but it was determined that she had multi-drug resistant tuberculosis (MDR-TB).
Her doctors responded by administering an injectable treatment – a long-standing treatment approach for MDR-TB in which people receive daily injections over the course of many months. This treatment’s potential side effects include hearing loss and kidney failure.
When Noludwe’s kidney function began to decline, her doctors halted the regimen and sought other options, one of which was a new TB drug, with less severe side-effects, called bedaquiline. This drug is one of the first new medicines to be developed for TB in many years, sparing patients the pain of daily injections, and the risk of permanent hearing loss or kidney failure.
Listen to Noludwe’s story, in her own words
Data from South Africa has shown that bedaquiline has fewer side effects and increased treatment success. The South African Department of Health, which recently moved to make bedaquiline available to MDR-TB patients as a standard treatment option, is leading the way in the provision of more people-centred TB regimens. South African officials expect this new treatment approach, which is shorter and less toxic, to improve adherence and ensure better outcomes.
Innovation and the continued development of antiretroviral therapies has transformed HIV treatment and led to the decrease of AIDS-related deaths globally. Today AIDS has ceased to be the leading killer among communicable diseases. However, TB, which is treatable and curable, has taken its place. TB is also the number one killer of people living with HIV, accounting for 40% of all HIV-related deaths in 2016. These linked epidemics require an integrative response.
TB and HIV communities are leaning into the lessons learned from the HIV response, by calling upon heads of states and governments to attend the UN High-Level Meeting on TB and commit to the following five actions:
- Transform the TB/HIV response to be more equitable, rights based and people centred.
- Galvanize stakeholders at all levels and ensure effective use of all available resources to address TB/HIV co-infection.
- Reach all people living with TB/HIV co-infection by eliminating gaps and barriers in access to prevention, diagnosis and treatment.
- Accelerate the development and implementation of new prevention, diagnostic and treatment tools and technologies to address TB/HIV co infection.
- Commit to rigorous monitoring and evaluation of programmes that are in place and ensure that TB/HIV targets are included in country-level accountability frameworks.
Together, these actions can:
- Combat TB and HIV stigma, and empower people through knowledge of their TB and HIV status.
- Improve multidisciplinary services according to World Health Organization guidelines.
- Increase access to services and uptake of early detection and treatment of TB in people living with HIV.
Read the full TB 2018 statement to global leaders – Together we can prevent two million deaths by 2022 – at www.tb2018.org.
Take part and send a message to YOUR head of state on Twitter.
Learn more here.