Institution: THSTI, Faridabad
Country of work: India
What is your motivation for engaging in HIV cure and remission research?
I have been working in the field of HIV/AIDS for the past 10 years. My Ph.D thesis was on the generation and characterization of recombinant human monoclonal antibodies by phage display technology. Attending this Research for Cure Academy meeting will give me an opportunity to interact with eminent scientists and fellow researchers who are working in the field of HIV cure. It will also enable me to get a grasp of the recent developments in HIV cure research and also help me in future collaborations.
What is your current area of research?
My main research focus is on engineering HIV-1 Env based antigens, assess their suitability in isolation of anti-HIV-1 human monoclonal antibodies and also for rational immunogen design. I am currently working on designing, development and characterization of novel HIV immunogens by high end protein engineering and stabilization. Two well characterized HIV-1 Envs are currently being assessed for their ability to elicit neutralizing antibody response in rabbits. In addition, these two well-ordered gp140 Envs are being utilized as antigens for sorting memory B cells towards our effort in isolation of cross neutralizing monoclonal antibodies.