Early Infant Diagnosis and Beyond
19 July 2015 | ILF/CIPHER Thematic Roundtable on Paediatric HIV Diagnostics, Vancouver, Canada (By invitation only)

From development to implementation, there are many challenges in paediatric HIV diagnostics. Indeed, although the 2013 WHO guidelines recommended testing infants at risk of perinatal HIV infection between 4-6 weeks by virological testing, there are discussions around testing at birth to ensure that treatment can start as soon as possible, especially before mortality peaks around three months. Beyond testing at birth and the PMTCT cascade, the diagnostics needs of infants and children will require integration in other healthcare platforms. As children age into adolescence and transition into adulthood, diagnostics will remain essential and, for treatment-experienced infected children, viral load monitoring and genotyping will become more important. It is hoped that this thematic roundtable will cover these and other issues bridging the industry, programming, regulatory and normative guidance spheres.

This meeting started by looking at the paediatric diagnostics continuum, from development to implementation, highlighting challenges along the way and existing initiatives. An overview of WHO guidance as well as insights working-up to the next revision of the 2013 Consolidated Guidelines was also provided. The bulk of the time available was for a group discussion on creative solutions to overcome barriers to development and delivery of optimal paediatric HIV diagnostics.



Meeting material

  • Related documents
  • Presentations
  • Multimedia

Introduction
Marissa Vicari, International AIDS Society, Switzerland - Manager, CIPHER and Sébastien Morin, International AIDS Society, Switzerland - Research Officer, ILF

Presentation

Challenges along the paediatric HIV diagnostics continuum: Development and implementation
Maurine Murtagh, London School of Hygiene & Tropical Medicine, United Kingdom

Presentation

Overview of existing initiatives

International Diagnostics Centre (IDC)
Rosanna Peeling, London School of Hygiene & Tropical Medicine, United Kingdom

Presentation

EID Consortium
Sergio Carmona, NHLS, South Africa, presented by Maurine Murtagh, London School of Hygiene & Tropical Medicine, United Kingdom

Presentation

HIV Global Diagnostics Working Group (GDWG)
Anita Sands, WHO, Switzerland

Presentation

WHO/CDC/NHLS Joint Assessment Mechanism for In Vitro Diagnostics
Anita Sands, WHO, Switzerland

Presentation

Diagnostics Access Initiative (DAI)
Anisa Ghadrshenas, CHAI, Kenya

Presentation

WHO guidance on paediatric HIV diagnostics
Martina Penazzato, WHO, Switzerland - CIPHER STAC member

Presentation

Discussion on creative solutions to overcome barriers to development and delivery of optimal paediatric HIV diagnostics (technology and programming)

Facilitator: Trevor Peter, CHAI, Botswana

Presentation

  1. Bottlenecks and solutions in paediatric HIV diagnostics
    • Manufacturers’ perspective
    • Primary discussant: Duncan Blair (Alere, Thailand)
    • Implementers’ perspective
      Primary discussant: Chewe Luo (UNICEF, USA)
  2. Early infant diagnosis
    Primary discussant: Natella Rakhmanina (EGPAF, USA)
  3. Viral load monitoring
    Primary discussant: Teri Roberts (MSF, Switzerland)
  4. Looking at the future: Genotyping and resistance testing
    Primary discussant: Robert Luo (Roche Molecular Systems, USA)
     

Summary and closing comments
Marissa Vicari, International AIDS Society, Switzerland - Manager, CIPHER and Sébastien Morin, International AIDS Society, Switzerland - Research Officer, ILF

Presentation

Photo gallery