Global Fellows Research Academy
Jean Baptiste N'takpé
Institution: PACCI, ANRS site in Côte d’Ivoire
Country of work: Côte d'Ivoire
What is your motivation for engaging in HIV cure and remission research?
I am a physician, clinical trial manager. I obtained 3 university degrees (Methods in epidemiology, Statistical and Statistical regression) and a Master of Public Health. These trainings were undergone at Bordeaux University. The experiences and knowledge acquired from these positions and trainings aroused in me the desire to advance my research career with a PhD in epidemiology. My PhD theme is “HIV Controllers in Africa: benefits or risks of early ART”. This is an exceptional population for whom a good understanding of the mechanisms of controlling viral replication could be a challenge for developing an HIV-1 cure.
What is your current area of research?
I am within a team that has worked for 20 years on “early treatment” of people living with HIV, and conducted many trials including Temprano (N Engl J Med 2015) which demonstrated that early HAART and Izoniasid Preventive Therapy significantly reduce severe morbidity (44%) and mortality (35%). This result contributed to WHO 2015 recommendation. Concurrently with the management of clinical trial (REFLATE ANRS 12300), i am interested in the HIV controllers profile, which are my PhD thesis topic. My objectives are to characterize HIV Controllers (HIC), describe the benefits or risks of early ART among HIC, investigate clinical, socio-economic and biologic factors associated with HIV disease progression and establish an HIC cohort in Africa in collaboration with international HIC cohorts (ANRS CODEX).