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Abstract
Body composition in men with lipodystrophy enrolled in the multicenter AIDS cohort study Johns Hopkins University, Baltimore, Northwestern University, Chicago, University of Pittsburgh, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Los Angeles
A. Dobs1, T. Brown1, M. John1, F. Palella2, J. Chmiel2, M. Witt3, L. Kingsley4
Background: Changes in fat redistribution are common among HIV-infected persons, and have been attributed to antiretroviral therapy. The relationship of observed lipodystrophy with measures of body composition has not been clearly defined.
Methods: We enrolled men from the Multicenter AIDS Cohort Study who were HIV-seropositive with self-reported lipodystrophy (HIV+ LD+), and compared them to two groups of controls: HIV-seropositive without any symptoms or metabolic abnormalities (HIV+LD-) and HIV- negative controls (HIV-LD-). Both controls were matched for age within +5 yrs. DEXA scans detected the quantity of fat, lean tissue, and bone density and CT scans to determine the viscera vs. peripheral distribution of body fat.
Results: Table 1: Lists the antrhopomorphics and body composition results by CT, adjusted for BMI.
| | HIV-
n=31 | HIV+Lipo-
n=23 | HIV+Lipo+
n=39 | p-value | | BMI | 28.6 (0.9) | 26.9 (1.0) | 24.0 (0.8) | <0.0010 | | Waist-Hip ratio | 0.946 (0.01) | 0.948 (0.01) | 0.977 (0.009) | 0.0452 | | Hip (cm)circumference | 100.4 (1.1) | 97.5 (1.2) | 95.8 (1.0) | 0.015 | | Thigh (cm)circumference | 53.6 (0.8) | 51.6 (0.9) | 50 (0.8) | 0.0135 | | Visceral adipose tissue (abdomen) | 132 (11.4) | 97.2 (12.8) | 144 (10.2) | 0.0169 | | Subcutaneous adipose abdomen | 217.1 (16.2) | 141.4 918.1 | !52.4 (14.5) | 0.0034 | | Total adipose abdomen | 664.1 (34.9) | 496.0 (29.1) | 613 (31.3) | 0.0058 | | Subcutaneous adipose thigh | 104.2 (10.2) | 68.5 (11.5) | 58.7 (9.2) | 0.0059 | | Total adipose thigh | 444.5 (22.9) | 345.7 (25.6) | 388 (20.5) | 0.0168 |
Conclusions: Self-reported lipodystrophy was associated with consistent differences in body composition as measured by DEXA and CT of the abdomen. Compared to our two control groups, HIV+LD+ men had lower BMI, subcutaneous adipose tissue, and anthropomorphic circumferences, but increased visceral adiposity.
AIDS 2006 - XVI International AIDS Conference
Abstract no.
MOPE0293
Suggested Citation
"A.Dobs, et al.
Body composition in men with lipodystrophy enrolled in the multicenter AIDS cohort study Johns Hopkins University, Baltimore, Northwestern University, Chicago, University of Pittsburgh, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Los Angeles.
:
AIDS 2006 - XVI International AIDS Conference:
Abstract no.
MOPE0293"
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