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Abstract
Thyroid function in older men who are HIV-positive or at risk for HIV
M. Wiener1, R.S. Klein2
Background: With the advent of HAART, persons with HIV infection are living to older ages and are at risk for disorders of aging. The objective of this study was to evaluate the prevalence of and factors associated with abnormal thyroid function in older men with or at risk for HIV.
Methods: We performed a cross-sectional analysis of baseline data in a prospective cohort study of men ³49 years old with or at risk for HIV infection. Men had semi-annual standardized interviews, and BMI, HIV serology, CD4+ counts, HIV viral load, hepatitis C serology, thyroid stimulating hormone (TSH) and free T4 levels were performed. Data were analyzed using Wilcoxon rank-sum, Kruskal-Wallis, Chi-square, Fisher’s exact, and Spearman rank tests.
Results: Characteristics of 643 men studied: 53% black; 26% Hispanic; 38% overweight; 19% obese; 57% HIV+; 72% hepatitis C seropositive; cocaine or heroin use: 90% ever and 38% during prior six months. TSH was low in 9% and elevated in 4%. Of 58 with low TSH, free T4 was high in two and low in two. Of 26 with elevated TSH, one had low free T4. HIV+ men had significantly higher TSH (P=.005) and lower free T4 (P<.0001) than HIV- men. Blacks were more likely to have low TSH (P=.012), and whites more likely to have high TSH (P=.02). HIV- men who used cocaine or heroin within 6 months had lower TSH than those who abstained (P=.0054); there was no significant difference among HIV+ men. Exclusion of seven men taking medication for thyroid disease did not affect the findings.
Conclusions: Abnormal TSH levels were noted in 13% of older men with or at risk for HIV infection. The associations of drug use, race, and HIV infection with abnormal thyroid function warrant further investigation.
AIDS 2006 - XVI International AIDS Conference
Abstract no.
MOPE0280
Suggested Citation
"M.Wiener, et al.
Thyroid function in older men who are HIV-positive or at risk for HIV.
:
AIDS 2006 - XVI International AIDS Conference:
Abstract no.
MOPE0280"
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