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Abstract
Prevalence and predictors of metabolic syndrome among HIV-positive and negative women
M.E. Sobieszczyk1, D.R. Hoover2, K. Anastos3, K. Mulligan4, T. Tan5, C. Hyman6, M.H. Cohen7, S.R. Cole8, J. Justman9, Women's Interagency HIV Study
Background:
The prevalence of the metabolic syndrome has been described in general populations and appears to be rising, particularly among women. But little is known about prevalence and risk factors of this syndrome among HIV-infected women.
Methods:
Prevalence was assessed among HIV-positive and negative women in the Women’s Interagency HIV Study (WIHS) seen from October 2000 to October 2004. The syndrome was defined using NHLBI criteria as >3 of: (1) waist circumference >88 cm; (2) triglycerides >150mg/dL or treatment for hypertriglyceridemia; (3) HDL-cholesterol <50 mg/dL or treatment for reduced HDL; (4) blood pressure >130 systolic or >85 diastolic or treatment for hypertension; (5) fasting glucose >100 mg/dL or antidiabetic medication.
Results:
Of the 668 HIV-negative and 1726 positive women who provided fasting samples for >=1 visit, the syndrome was more prevalent among the infected (33%) than uninfected (22%) women (OR = 1.8, p<0.0001). HIV-positive women were more likely to have hypertriglyceridemia (OR = 2.7, p<0.0001) and low HDL (OR = 2.5, p<0.0001) than HIV-negative women. Increased triglycerides and low HDL were the most common components present among those with the syndrome for both HIV-positive and negative women. 32% and 29% of HIV-infected women were on PI-based and non-PI based HAART, respectively.
In multivariable analyses, the syndrome was positively associated with higher BMI, older age and smoking (OR = 10.9, 1.4, and 1.3 respectively; p<0.0001 for all). Plasma HIV viral load >50,000 copies/mL predicted the syndrome (OR = 1.4, p=0.02), as did stavudine use (OR = 1.3, p = 0.008); nevirapine use was protective (OR = 0.8, p=0.015).
Conclusions:
Metabolic syndrome is more prevalent in HIV-infected than HIV-uninfected women. Increased prevalence is associated with older age and other traditional risk factors in both groups. For HIV-infected women, higher HIV viral load levels and use of stavudine were associated with an increased prevalence of metabolic syndrome.
AIDS 2006 - XVI International AIDS Conference
Abstract no.
WEPE0147
Suggested Citation
"M.E.Sobieszczyk, et al.
Prevalence and predictors of metabolic syndrome among HIV-positive and negative women.
:
AIDS 2006 - XVI International AIDS Conference:
Abstract no.
WEPE0147"
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