The risk factor and prevalence of transmitted antiretroviral drug resistance in treatment-naïve HIV-infected individuals in Southern Taiwan
Background: The transmission of drug-resistant (TDR) HIV-1 strains might compromise the efficacy of current first-line antiretroviral treatment and has become a public health concern. Rate of TDR strains in treatment-naïve patients was influenced by duration of infection and selection of study populations.
Methods: A prospective study on TDR was conducted in antiretroviral therapy -naïve HIV-1 -infected individuals of HIV anonymously screening program from 2007 to 2009 in Southern Taiwan. Drug resistance genotyping was performed on subjects' plasma. Drug resistance mutations were determined by ViroSeqTM system. Risk factor for TDR was analyzed by logistic regression model.
Results: From 2007 to 2009, total of 3697 individuals received a free HIV anonymously screening test. The positive rate for HIV-1 infection was 5.4%, 4.2% and 3.7%, respectively. Sequences were obtained from 78 individuals, of whom 84.6 % were infected by MSM, and 15.4 % were infected by heterosexually. Subtype B HIV-1strains were found in 98.7 %, and subtype C in 1.3 %. Nine (11.5 %) were found to harbor drug resistance strains. The rates of resistance to any three classes of ART were 17.6% in 2007, 13% in 2008 and 8% in 2009. The most common NRTI resistance associated mutation was M184V, K219N and T215S/P. The most common NNRTI resistance associated mutation was Y181C, K103N, V179D and Y318F. No any PI resistance associated mutation was found in these 3 years. Hepatitis B infection (OR 14.5, CI 2.2-96.4, p=0.006) and multiple sexual partners (OR 7, CI 1.1-44.7, p=0.04) increased the risk of harboring HIV drug resistance strains by logistic regression model.
Conclusion: The rate of TDR was relatively low and decreased gradually in these 3 yeas in Southern Taiwan since introduce of free ART program in 1997. Surveys among recently HIV-infected subjects should be performed continually to ensure the success of the scale-up antiretroviral treatment.
6th IAS Conference on HIV Pathogenesis and Treatment
"I.T.Chen, et al.
The risk factor and prevalence of transmitted antiretroviral drug resistance in treatment-naïve HIV-infected individuals in Southern Taiwan.
6th IAS Conference on HIV Pathogenesis and Treatment: