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Abstract
NEUROPATHOLOGY IN HIV/AIDS - AN AUTOPSY STUDY
S.B. Kulkarni, L.D. Bhandarkar, R.J. Rao
Department. of Pathology, Grant Medical College and Sir J.J. Hospital, Byculla, Mumbai 08, India
Introduction: High prevalence of HIV infection is observed in India. Many patients of HIV infections develop neurological complications due to opportunistic infections and primary lymphomas. Hence, this study was carried out to categorize the neuropathological lesions in HIV patients.
Method: A retrospective and prospective neuropathological autopsy study was carried out, between 1993 and 2001, in 61 HIV positive patients with neurological signs and symptoms in the neuropathology department of a tertiary level medical centre in Mumbai, India.
Results: Central nervous system lesions were observed in 57 / 61 (93%) cases. Opportunistic infections were present in 45 cases. These included parasitic infections in 19 (31%) cases (toxoplasmosis-16, neurocysticercosis-2, acanthamoeba-1), fungal infections in 11 (18%) cases (cryptococcosis-10, candidiasis-1), bacterial infections in 9 (15%) cases (tuberculosis-7, pyaemic abscesses-2) and cytomegalovirus infection in 6 (10%) cases. Primary HIV related lesions were seen in 13 (21%) cases (HIV encephalitis-9, progressive multifocal leukoencephalopathy-3, HIV Leukoencephalopathy-1). Neoplastic lesions observed included 1 case each of primary CNS lymphoma, leukemic spread and metastasis of adenocarcinoma.
Conclusion: High prevalence of HIV related lesions and opportunistic infections are common. Although not reported from India in the pre-AIDS era, toxoplasmosis was the most frequently observed infection in our study. These observations are important to plan diagnostic and therapeutic approach in developing countries.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
879
Suggested Citation
" S.B. Kulkarni, et al.
NEUROPATHOLOGY IN HIV/AIDS - AN AUTOPSY STUDY.
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
879"
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