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Abstract
PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HIV-1 INFECTION: INITIATIVES OF THE UNITED STATES PHARMACOPEIA DRUG QUALITY AND INFORMATION PROGRAM (USP DQI)
D. Seyoum, N.L. Blum
The United States Pharmacopeial Convention, Inc., Global Assistance Initiatives, 12601 Twinbrook Parkway, Rockville, Maryland 20852-1970, USA
Many countries with limited resources have not been able to implement the PACTG 076 zidovudine regimen because of its complexity and cost. The objective of this study was to compare nevirapine, short-course zidovudine, and short-course zidovudine plus lamivudine regimens for safety, effectiveness, ease of administration, and cost-effectiveness in the prevention of MTCT of HIV-1 infection in resource-poor countries;
Members of the USP Drug Information Expert Committees reviewed the published clinical trials on nevirapine, short-course zidovudine, and short-course zidovudine plus lamivudine regimens presented to them in the form of evidence tables. Published clinical trials were analyzed based on their evidence ratings. The evidence tables were based on evidence ratings. The main outcome of the study was safety, effectiveness, ease of administration, and cost-effectiveness;
The short-course zidovudine and short-course zidovudine plus lamivudine regimens were inferior to that of the PACTG 076 regimen. The administration of a single dose of nevirapine to the mother intrapartum and to the infant postpartum effectively reduces MTCT of HIV-1 and is less costly and easy to administer than the other antiretroviral regimens; however, mutations conferring resistance to nevirapine could be observed after a single dose even with a low level of viral replication;
Based on these results, members of the USP Drug Information Expert Committees recommended that in the developed world the use of nevirapine should be restricted to previously untreated women with HIV-1 infection who present in labor; however, in resource-poor countries nevirapine may be considered as one of several strategies in the prevention of MTCT of HIV-1 infection.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
1072
Suggested Citation
" D. Seyoum, et al.
PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HIV-1 INFECTION: INITIATIVES OF THE UNITED STATES PHARMACOPEIA DRUG QUALITY AND INFORMATION PROGRAM (USP DQI).
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
1072"
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