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Abstract
SEROPREVALENCE OF HCV AMONG HIV-POSITIVE COMPARED TO HIV-NEGATIVE PREGNANT WOMEN IN YAOUNDE, CAMEROON
R. Njouom1, C. Pasquier2, A. Ayouba1, A. Kfutwah1, M.C. Tejiokem1, J. Mfoupouendoun1, B. Njinku1, G. Tene3, M. Mony Lobe3, J. Thonnon1, J. Izopet2, E. Nerrienet1
1Laboratoire de virologie, Centre Pasteur du Cameroun, Yaounde, Cameroon, 2Laboratoire de virologie, CHU Toulouse Purpan, Toulouse, France, 3Centre Mère-Enfant, Fondation Chantal Biya, Yaounde, Cameroon
Background: HCV and human immunodeficiency virus (HIV) share similar transmission characteristics; therefore, co-infections due to these viruses are common among HIV infected patients, the prevalence depending on the HIV-transmission category.
Objectives: The aim of this study was to determine and compare HCV seroprevalence among HIV-positive and HIV-negative pregnant women in Yaounde. Methods: Two thousand five hundred and fifty four consecutive pregnant women participating in a pilot public health program (PPHP) for the reduction of mother-to-child transmission of HIV-1 in Yaounde, Cameroon were enrolled. The presence of anti-HCV antibodies was checked using a commercial third-generation ELISA. Information concerning the HIV status was obtained through the PPHP.
Results: HCV antibody prevalence was 1.9 % (49/2554; 95 % CI: 1.4 – 2.5 %) and HIV prevalence was 8.5 % (217/2554; 95 % CI: 7.4 – 9.6 %). Similar HCV seroprevalence was found among HIV-positive (1.8 % (4/217); 95 % CI: 0.6 – 5.0 %) compared to HIV-negative pregnant women (1.9 % (45/2337); 95 % CI: 1.4 – 2.6 %) (P = 0.8).
Conclusion: This absence of difference in anti-HCV prevalence among HIV-positive compared to HIV-negative pregnant women in Yaounde may suggest that HCV sexual transmission is not common in this population, and that HIV infection does not enhance susceptibility to HCV sexual transmission. However, because of the existence of false-negative anti-HCV results among HIV-positive patients, further investigations using molecular HCV tests are required to confirm this finding.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
967
Suggested Citation
" R. Njouom , et al.
SEROPREVALENCE OF HCV AMONG HIV-POSITIVE COMPARED TO HIV-NEGATIVE PREGNANT WOMEN IN YAOUNDE, CAMEROON.
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
967"
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