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Abstract
LOW RATE OF HIV-1 MOTHER-TO-CHILD TRANSMISSION (MTCT) UNDER NEVIRAPINE INTERVENTION IN A PILOT PUBLIC HEALTH PROGRAM IN YAOUNDE, CAMEROON
A. Kfutwah1, A. Ayouba1, G. Tene 2, Y. Foupouapouognigni1, E. Menu3, J. Thonnon1, G. Scarlatti4, A.E. Nlend5, F. Barré-Sinoussi3, P.M.V. Martin1, E. Nerrienet1, for the Yaounde and European Network for the study of in utero transmission of HIV-1
1Centre Pasteur du Cameroun, BP 1274 Yaoundé, Cameroun, 2The Chantal Biya Foundation, Yaounde, Cameroon, 3Unité de biologie des retrovirus, Institut Pasteur, Paris, France, 4DIBIT San Rafaelle, Milano, Italy, 5Cameroon national AIDS control committee
Objective: To determine the percentage of infected children with NVP used to prevent peripartum HIV mother-to-child transmission (MTCT) in Yaounde, Cameroon.
Design: The study was a prospective Public Health pilot program (PHPP) covering a three years period (January 2000-December 2002).
Setting: The study was performed in three contiguous sites comprising the mother-child health care centre of the Chantal Biya Foundation, the Yaounde Central Hospital and the Centre Pasteur du Cameroun.
Subjects: Children born to nevirapine treated women in the framework of the PHPP. These children have been regularly followed and diagnosed for HIV-1 infection at 6-8 weeks and 5-6 months.
The intervention consisted to deliver single dose NVP to counselled and consenting pregnant women and their babies according to the HIVNET012 protocol. Diagnosis of HIV-1 infection was achieved through plasma viral load quantification with the b-DNA system.
Results:123 children were diagnosed for perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen (10.6%, 13/123; 95% CI [5.14-16]) were infected. Two children remained with intermediate viral load at both time points. 108 (87.8%) were considered non-infected at 6-8 weeks of age.
Conclusions: Our results indicate that the HIV-1 MTCT rate at 6-8 weeks under NVP ranged between 10.6% and 12,2%. This confirm the effectiveness of NVP to lower the risk of HIV-1 MTCT. Further studies are needed to better evaluate whether persistent NVP-resistant virus may affect the effectiveness of NVP in pregnant women since NVP is becoming widely used in developing countries.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
1073
Suggested Citation
" A. Kfutwah , et al.
LOW RATE OF HIV-1 MOTHER-TO-CHILD TRANSMISSION (MTCT) UNDER NEVIRAPINE INTERVENTION IN A PILOT PUBLIC HEALTH PROGRAM IN YAOUNDE, CAMEROON.
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
1073"
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