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Abstract
INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSED BY CERVICAL MACROPHAGES IN HIV WOMEN CO-INFECTED BY HUMAN PAPILLOMA VIRUS (HPV)
A.T.G. Fernandes1, A. Nicol1, F. Silva1, B. Grinstejn1, F. Russomano1, O. Martinez-Maza2, M.G. Bonecini-Almeida1
1Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 2University of Califórnia, Los Angeles, USA
HPV infection undergoes a period of clinical latency, but reappears frequently in HIV seropositive women, whose have great susceptibility to develop cervical cancer disease. Local immunity response play a critical role in controling these infections. Furthermore, HIV and HPV can modulate macrophage apoptotic pathways through several mediators, including cytokines and nitric oxide. The aim of this study was to analyze the frequency and distribution of macrophage and iNOS in cervical HPV infection. Twenty biopsies from uterine cervix HPV infected women) had been processed for imunohistochemistry to identify the presence of macrophages and iNOS. The patients have been divided in two groups: group I (n=10) HIV-/HPV+ and group II (n=10) HIV+/HPV+. We observed a markable macrophage infiltration but there is no difference in its distribution into the epithelium (0.42(0.05 and 0.47(0.21), subepithelium (5.89(0.92 and 6.04(0.44), corion (5.83(0.51 and 5.94(0.54) and periglandular areas (2.37(0.50 and 2.19(0.42) among the studied groups. In addition, we observed iNOS expression in all areas, especially in subepithelium (10.68(0.76 and 9.78(0.30) in both groups. The co-localization of iNOS and the cellular intraepithelium neoplasia may be correlated to the regulation of HPV infection and more detailed studies should be addressed to respond the role of this molecule in the control of cervical cancer in HIV infected women.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
402
Suggested Citation
" A.T.G. Fernandes , et al.
INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSED BY CERVICAL MACROPHAGES IN HIV WOMEN CO-INFECTED BY HUMAN PAPILLOMA VIRUS (HPV).
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
402"
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