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Abstract
ANTIRETROVIRAL THERAPY DURING TUBERCULOSIS TREATMENT IN BRAZIL
F.S. Marinho, M.A. Vieira, M.C.S. Lourenço, S. Souza Carvalho, M.G. Morgado, V. Rolla
Instituto de Pesquisa Clinica Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil
Introduction: tuberculosis (TB) is the most common opportunistic infection associated with AIDS in Brazil and TB treatment concomitantly with HAART is still a challenge.
Objective: to describe the efficacy of HAART concomitantly to TB treatment.
Methods: prospective longitudinal descriptive study in a cohort of HIV positive patients diagnosed with TB from July 2000 to December 2002. Inclusion criteria: HIV+ patients with TB diagnosis. Exclusion criteria: less than 120 days of follow-up. TB treatment recommended in Brazil is: rifampicin 600mg, isoniazid 400mg and pirazynamid 2000mg during 6 months. Efficacy of ARV was defined as viral load <80 copies from month 4 to month 10 after TB treatment. Results were analyzed considering the frequencies and mean values of each variable.
Results: Were included 89 patients: 56 (63%) males and 33 (37%) females. The clinical forms of TB were pulmonary (45), extra pulmonary (34) and disseminated (10). Mean CD4 counts close TB diagnosis was 223 cell/mm3 ((219) and mean viral load 5 log ((0.9)
From the 48 na´ve patients 11 (22%) were treated with regimens containing efavirenz and 5/11 (45%) achieved VL<80 copies. From 15/48 (31%) patients treated with ritonavir/saquinavir, 4/15 (26%) obtained VL < 80 copies. The remaining na´ve patients did not use HAART.
Among previous treated patients 24/39, received efavirenz and 16% (4/24) obtained VL<80 copies. In the ritonavir/saquinavir group 2/7 (28%) patients achieved VL<80 copies.
Conclusion: Our results showed a low proportion of patients who achieved undetectable viral load after TB treatment concomitantly with HAART with both regimens evaluated.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
883
Suggested Citation
" F.S. Marinho, et al.
ANTIRETROVIRAL THERAPY DURING TUBERCULOSIS TREATMENT IN BRAZIL.
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
883"
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