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Abstract
ANTIFUNGAL ACTIVITY OF NUCLEOSIDE ANALOGUES AND NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
M. Calatroni1, S. Mata2, S. Magaldi2, C. Hartung 2, C. Pérez2, M. Colella2, C. Olaizola2, L. Henao1
1Fundación Amigos de la Vida, Caracas, Venezuela, 2Medical Mycology Department, Institute of Tropical Medicine, Universidad Central de Venezuela, Venezuela
Venezuela is endemic for most of the fungal deep mycoses. The majority of our HIV patients are currently not receiving antifungal prophylactic therapy. Nevertheless, we observed in our HIV patients with HAART treatment, receiving mainly nucleoside reverse transcriptase inhibitors (NRTIs) or non-nucleoside reverse transcriptase inhibitors (NNRTIs), a decreasing trend of fungal opportunistic infections (OFIs), even before recovery of CD4+ cell count was achieved.
An epidemiological, clinical and immunological longitudinal study was carried out. 139 out of 641 HIV infected subjects were studied.
To assess in vitro antifungal activities of NRTIs (Zidovudine, Lamivudine and Stavudine) and NNRTIs (Efavirenz) against Candida sp. and Cryptococcus neoformans .We used the well diffusion test (WD) and the NCCLS reference broth microdilution method. 39 isolates of Cryptococcus neoformans and 67 isolates of Candida spp. were tested.
Our results demonstrated that the NCCLS and WD method yielded a satisfactory distribution of susceptibility patterns in Cryptococcus and some Candida spp. Efavirenz had an antifungal activity mainly against Cryptococcus whilst NRTIs showed an antifungal activity mainly against Candida spp. It is as far as we know, the first time that any antifungal susceptibility patterns are reported and strongly suggest, whatever its source and mechanisms, that there might be an antifungal effect of NNRTIs and NRTIs.
Key words: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), susceptibility, Candida spp, Cryptococcus neoformans.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
904
Suggested Citation
" M. Calatroni , et al.
ANTIFUNGAL ACTIVITY OF NUCLEOSIDE ANALOGUES AND NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS.
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
904"
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