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Abstract
CHARACTERISTICS OF SERUM IgA IN HIV-2-EXPOSED UNINFECTED INDIVIDUALS
L. Qin1-2, C. Nilsson1-2, S. Andersson3, M. Ehnlund2, S. Sourial1, E. Björling1-2
1Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden 2The South Hospital, Research Center, Karolinska Institute, Stockholm, Sweden 3Swedish Institute for Infectious Disease Control, Karolinska Institute, Stockholm, Sweden
The mechanisms behind the resistance of human immunodeficiency virus type 2 (HIV-2)infection are still not fully understood. In the present study, we explore the HIV-2 specific humoral serum immunoglobulin A (sIgA) immune response in HIV-2-exposed uninfected (EU) individuals.
Serum samples from heterosexual EU females and their known HIV-2 infected partners and controls originating from Guinea-Bissau in Africa were studied. Antibody reactivity to native and recombinant envelope glycoproteins was investigated. The capacity of purified sIgA to neutralize the HIV-2SBL6669 strain was tested.
Preliminary results showed that the majority of EU samples showed reactivity against whole HIV-2 antigen and with recombinant gp36 (rgp36), no sample was positive against native HIV-2 gp125 and a few samples showed recombinant gp105 (rgp105) reactivity. The antigenic pattern for the HIV-2 positive partners showed that all sIgA samples or almost all were reactive to whole HIV-2 antigen and rgp36 respectively. For gp125 and rgp105, a few samples exhibited binding for both proteins. When comparing the average IgA concentration in serum, the EU group had higher concentration compared to the healthy controls Furthermore, neutralization test with purified sIgA antibodies from both EU and HIV-2 positive individuals against the HIV-2SBL6669 strain. This work will contribute to our understanding of the resistance to HIV-2 infection.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
393
Suggested Citation
" L. Qin -2, et al.
CHARACTERISTICS OF SERUM IgA IN HIV-2-EXPOSED UNINFECTED INDIVIDUALS.
Poster:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
393"
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