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Abstract
MANNOSE-BINDING LECTIN (MBL) ALLELES IN SUB-SAHARAN AFRICANS AND RELATIONSHIP WITH SUSCEPTIBILITY TO INFECTIONS
L.E. Mombo1-2, C.Y. Lu1, S. Ossari1, I. Bedjabaga1, L. Sica1, R. Krishnamoorthy2, C. Lapoumeroulie2
1Centre International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon, 2Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 458, Hôpital Robert Debré, Paris, France
Mannose-binding lectin (MBL) plays an important role in the early stages of primary infections and during the decay of maternal antibodies in infants. Various studies have looked at the relationship between serum MBL concentrations, MBL gene alterations and susceptibility to infections.
We investigated the distribution of variant MBL alleles in 626 unrelated adults from sub-Saharan African countries and looked for a potential relationship between these alleles and the incidence, prevalence and death rate of tuberculosis for sub-Saharan Africa. We also evaluated the relationship between MBL genotypes and susceptibility to HIV-1 infection in 188 Gabonese adults.
We found that i) the prevalence of the common variant MBL alleles is correlated with the incidence of tuberculosis in sub-Saharan Africa (r = 0.565), ii) the mutant MBL G57E allele, in either the homozygous or compound heterozygous state, is associated with susceptibility to HIV-1 infection in the Gabonese population (p = 0.019).
Our data plus those in the literature suggest that individuals who are homozygous for the mutant MBL alleles display increased susceptibility to infections. Interestingly, we found that individuals who are heterozygous for MBL mutations are much less susceptible to infections than those who are homozygous for the wild-type MBL allele.
The 2nd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
137
Suggested Citation
" L.E. Mombo -2, et al.
MANNOSE-BINDING LECTIN (MBL) ALLELES IN SUB-SAHARAN AFRICANS AND RELATIONSHIP WITH SUSCEPTIBILITY TO INFECTIONS.
Forum:
The 2nd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
137"
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