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Abstract
DIFFERENCES IN VIROLOGIC SUPPRESSION AMONG MEN AND WOMEN ENROLLED IN A POPULATION-BASED ANTIRETROVIRAL DRUG TREATMENT PROGRAM
O'CONNELL J, BRAITSTEIN P, HOGG R, YIP B, O'SHAUGHNESSY M, MONTANER J, BURDGE D
OBJECTIVES: To characterize the determinants of plasma HIV-RNA suppression to below 500 copies/mL in women and men in British Columbia, and to explore possible gender differences in plasma viral load suppression after antiretroviral therapy.
METHODS: This is a population-based analysis of antiretroviral therapy naïve HIV-positive men and women 18 years or older in British Columbia, Canada. Factors associated with gender and with plasma HIV-RNA viral load suppression to below 500 copies/mL at one year follow-up in patients treated with triple combination therapy were examined using non-parametric tests, and logistic regression analyses respectively. Potential predictors of viral load suppression were modeled using multivariate logistic regression techniques.
RESULTS: A total of 739 men and women (92 women and 647 men) were eligible. With treatment, 62.5% (462/739) of individuals (46.7% (43/92) of the women and 64.8% (419/647) of the men; p=0.001) suppressed HIV-RNA viral load to below 500 copies/mL. Virologically suppressed participants were more likely to be older (38 versus 35 years; p <0.001), have a baseline diagnosis of AIDS (16.2% versus 8.7%; p = 0.003), have lower median CD4 counts (270 cells/mm3 versus 340 cells/mm3 p=0.003), be 95% adherent (75.5% versus 32.5%; p = 0.001), and were less likely to be injection drug users (25.1% versus 41.5%; p = 0.001), than those who did not suppress viral load. Multivariate analyses indicated that gender is not significantly associated with HIV-RNA response (odds ratio 1.18; 95% CI: 0.72 -1.95) after adjusting for adherence, injection drug use and age.
CONCLUSION: Our data indicate that women being prescribed triple-combination antiretroviral therapy in British Columbia are not achieving viral load suppression to the same extent as men after one year. However, gender differences in virologic response to antiretroviral therapy are explained by known confounders such as age, adherence, and injection drug use.
The 1st. IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
62
Suggested Citation
"O'CONNELLJ, et al.
DIFFERENCES IN VIROLOGIC SUPPRESSION AMONG MEN AND WOMEN ENROLLED IN A POPULATION-BASED ANTIRETROVIRAL DRUG TREATMENT PROGRAM.
Oral Presentation:
The 1st. IAS Conference on HIV Pathogenesis and Treatment
:
Abstract no.
62"
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