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Abstract
Prevalence of Mycoplasma pneumoniae infections involving the respiratory tracts of HIV-infected patients using culture and serological methods in Chennai, India
E.M. Shankar1, N. Kumarasamy2, P. Balakrishnan2, S. Solomon2, A.R. Usha1
Background: The true prevalence of M. pneumoniae infections involving the respiratory tracts of HIV-infected individuals is still unclear. This study examined the prevalence of M. pneumoniae in 100 HIV-infected individuals at an AIDS care center in Chennai, India, using conventional laboratory techniques and interpretation criteria.
Methods: Diagnosis was based on culture, cold agglutination test, commercial enzyme-linked immunosorbent assay (ELISA) for the qualitative determination of IgM antibodies against M. pneumoniae and Serodia_myco II particle agglutination test. The efficacies of different diagnostic procedures were analyzed and the prevalence of other respiratory pathogens was also carried out.
Results: The prevalence of M. pneumoniae was 31% by culture and 21% by IgM ELISA. Cough (p=0.03), myalgia (p=0.04), rales (p=0.04) and cervical adenopathy (p=0.03) were the symptoms that corroborated with culture positivity significantly. Both culture and IgM ELISA positive cases revealed depletion in CD4 cell counts and were anaemic (p=0.01) compared to culture negative cases (p=0.001). S. pneumoniae was more common in the respiratory specimens.
Conclusions: This study unveils the prevalence of M. pneumoniae in HIV associated immunodeficiency nevertheless with the usage of old methods. Although, modern molecular techniques might provide more insight to prevalence of M. pneumoniae in HIV-infected individuals, conventional methods could still be used in resource-constrained settings.
AIDS 2006 - XVI International AIDS Conference
Abstract no.
MOPE0418
Suggested Citation
"E.M.Shankar, et al.
Prevalence of Mycoplasma pneumoniae infections involving the respiratory tracts of HIV-infected patients using culture and serological methods in Chennai, India.
:
AIDS 2006 - XVI International AIDS Conference:
Abstract no.
MOPE0418"
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