|
|
Abstract
The Serum And Urinary Trypsin Inhibitors Level Correlate With Progression Of HIV Infection
Papuashvili M.1
Introduction: It is known that HIV-infection is accompanied by essential changes in specific and non-specific type of organism protection system. It has been found that inhibitors of serine proteases, trypsin inter-a-inhibitor (ITI) and urinary trypsin inhibitor (UTI) are undergoing considerable changes as they are a part of general protection mechanism. The aim of the present research work was to study the presence of ITI in serum and UTI in urine among the HIV-infected patients at the different stages of disease (according to CDC classification).
Methods: UTI and ITI determination by domestic test-systems was performed. 93 HIV-infected patients and 20 healthy donors participated in this study.
Results: The presence of ITI in serum of blood among healthy donors was 256,24±32,311 mkg/ml and UTI concentration – 5,01±1,169 mkg/ml. The HIV patients with A1-A3 stages from the first group (n=23) demonstrated the low level of UTI in urine (1,57±0,208 mkg/ml) against a background of ITI high level in blood serum (374,65±21,871 mkg/ml). The second group (n=42) with B2-B3 stages testified the increased UTI presence in urine (24,48±4,103 mkg/ml) and stable high ITI level in blood serum (365,33±10,918 mkg/ml). Against a background of strong decreasing ITI concentration in blood serum (98,71±7,744 mkg/ml) the highest UTI level in urine (45,55±8,041 mkg/ml) was found in the third group (n=28) with terminal C1-C3 stages.
Conclusions: Inhibitors of serine proteases might belong to a system of sufficiently active endogenous suppressors of HIV-1. As soon as HIV-infection is proceeding to AIDS, the decompensation of non-specific protection system of inflammatory reactions provoke the biochemical disorders which are turned into inflammatory disaster of organism in general.
The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
WePe8.11B01
Suggested Citation
" Papuashvili M.
The Serum And Urinary Trypsin Inhibitors Level Correlate With Progression Of HIV Infection.
Poster Exhibition:
The 3rd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
WePe8.11B01"
|
|
|