|
|
Abstract
Echocardiographic Aspects In HIV Infected/AIDS Children And Adolescents
Tudor A.M.1, Mardarescu M.1, Petrea S.1, Anca I.2
Introduction: The aim of this study was to identify anatomic and functional cardiac aspects in children and adolescents with HIV/AIDS and to correlate them with CD4 levels and concomitant opportunistic infections.
Methods: We perform a retrospective study on 81 children and adolescents with HIV infection admitted in our Institute between 01.01.2000 and 31.12.2004. We used Doppler echocardiographic technique. The results obtained were compared with normal values for actual body surface and not for age. CD4 counts were determined using flowcitometry. Viral load was measured by Amplicor Roche and Abbott LCX.
Results: From 81 patients, 28 had normal cardiac parameters (group A). 4 patients had pericarditis associated with systemic or pulmonary tuberculosis. In 49 patients (group B) we found pathologic echocardiographic aspects.32 children had low left ventricle (LV) ejection fraction. 17 patients had enlarged LV volume, 4 had hypertrophic LV, and 2 had enlarged volume associated with hypertrophy of LV. Enlarged right ventricle volume was found in 18 children. In 8 cases there were enlarged both ventricles and in 2 cases we observed biventricular hypertrophy. CD4 count under 200 cells/mm3 was found in 26 patients from group B and in 9 from group A. In group B the most frequent opportunistic infection was tuberculosis -24 cases, followed by wasting syndrome – 13 cases and HIV encephalopathy – 9 cases. In contrast, in group A oropharyngeal candidiasis was the most frequent -7 cases, tuberculosis and HIV encephalopathy –2 cases each. Recurrent pulmonary infections were found in 16 patients in group B and in 8 patients in group A.
Conclusions: HIV cardiomiopathy was found more frequent in terminal stages (low CD4 count and AIDS defining manifestations). HIV itself was probably the first cause of heart injury in our study and not recurrent pulmonary infections. Additionally, HAART therapy and secondary metabolic abnormalities extend clinical and echocardiographic aspects.
The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
MoPe9.3C01
Suggested Citation
"TudorA.M., et al.
Echocardiographic Aspects In HIV Infected/AIDS Children And Adolescents.
Poster Exhibition:
The 3rd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
MoPe9.3C01"
|
|
|