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Abstract
Predicting Peripheral Arterial Disease in HIV-infected patients using Ankle-Brachial Index measurement
Spichler A.1, Spichler E.2, Spichler D.2
Background: The introduction of HAART regimens has substantially modified the course of HIV disease by lengthening patient survival. However, early data have raised concerns about an increase in Peripheral and Coronary Arterial disease. Ankle-Brachial Index (ABI) is a non-invasive, reliable measure for arterial disease, not described in HIV. Aim: To describe the ABI in HIV-infected adult patients.
Methods: In a prospective observational study started in January 2005, we have surveyed HIV-infected patients, at the outpatient center, with the ABI measurement.Inclusion criteria was HIV-infected patient with more than 40 yrs. ABI was assessed dividing the selected ankle pressure by the previously selected artery systolic brachial pressure .ABI < 0,9 was considered abnormal.
Results: Twenty-one HIV patients were studied. ABI was abnormal in 28,5%.In a linear analysis,76,1% were male. Median age was of 47±7. Skin color White/Non white was:76,2%/23,8%.Diabetes was present in 14,3%,and hypertension in 23,8%.Body Mass Index (BMI) was 24,8±3,4.Length of HIV was 3.7 yrs. Cholesterol ,LDL ,HDL, Triglycerides, were analyzed,respectively:189,5mg/dl;103,8mg/dl; 45 mg/dl;247,mg/dl.CD4 and Viral Load were:343 cel/mm3;14,352 copies respectively .Fifteen patients were on Antiretroviral treatment. Most were taking Zidovudine, Lamivudine and Efavirenz. There were statistically differences p <0,005 between ABI <0.9 and age, length of HIV, diabetes, hypertension, BMI, cholesterol, HDL, LDL, triglycerides and CD4 count.
Conclusions: ABI in HIV emphasizes new knowledge about peripheral arterial disease, even in a small population. Randomized trials using ABI will provide more information about whether HIV infection alone, antiretroviral treatment, or both, may increase risks for arterial diseases.
The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
TuPe2.3C02
Suggested Citation
"SpichlerA., et al.
Predicting Peripheral Arterial Disease in HIV-infected patients using Ankle-Brachial Index measurement.
Poster Exhibition:
The 3rd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
TuPe2.3C02"
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