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Abstract
Gender Differences in AIDS Clinical Trials: Attitudes and Perceived Barriers among People Living with HIV/AIDS from Racial/ethnic Minority Backgrounds
Gwadz M.V.1, Nakagawa A.2, Leonard N.R.1, Herzog N.2, Riedel M.3, Finkelstein M.1, Arredondo G.1, Tharaken M.1, Diggs A.1, Mildvan D.4
Introduction: Gender differences are described in willingness to participate in AIDS Clinical Trials (ACTs), and perceived barriers, among individuals living with HIV/AIDS in New York City.
Methods: 287 persons living with HIV/AIDS (59.4% male; 8% transgender) were recruited in 2004 from an AIDS service organization (47.6%) and community sampling. Participants completed a structured interview consisting primarily of previously validated measures. Data were analyzed using univariate and bivariate statistics.
Results: Participants were primarily African-American (55.7%) and Latino (33.7%), and receiving Medicaid (95.8%). There were few gender differences in demographic characteristics, although more men than women had injected drugs (42.9% versus 27.6%, X2 (1) 6.90, p. = .009). Knowledge of ACTs was poor (males = 54% correct, females 52%). Up to half reported barriers that reflected misconceptions about ACTs (e.g., that they would have to switch doctors to enroll; 43.2%). Regarding barriers, more women than men reported or tended to report concerns about receiving a placebo (56.3%, 33.3%, X2 (2) 6.26, p. = .044), confidentiality not being protected (42.5%, 30.9%, X2 (2) 5.18, p. = .075), being subjected to too many tests and procedures (71.9%, 47.3%, X2 (2) 5.92, p. = .052), and exclusion due to race/ethnicity (25%, 13%, X2 (2) 5.87, p. = .053).
Conclusions: The majority expressed willingness to enroll in ACTs, although with gender differences in the conditions under which they would do so. Both genders perceive a wide range of barriers to participation, many of which reflect a lack of knowledge of ACTs. Women have some unique barriers, including concerns about bias, confidentiality, and treatment, and, importantly, appear more risk-averse than men with respect to ACT participation. Gender-specific intervention strategies may be necessary to facilitate ACT participation.
The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
MoPe11.1C06
Suggested Citation
"GwadzM.V., et al.
Gender Differences in AIDS Clinical Trials: Attitudes and Perceived Barriers among People Living with HIV/AIDS from Racial/ethnic Minority Backgrounds.
Poster Exhibition:
The 3rd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
MoPe11.1C06"
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