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Abstract
AIDS Clinical Trials and Urban HIV+ Individuals from Racial/ethnic Minority Backgrounds: Knowledge, Attitudes, Barriers, and Facilitators
Nakagawa A.1, Gwadz M.V.2, Leonard N.R.2, Herzog N.3, Riedel M.4, Finkelstein M.2, Arredondo G.2, Tharaken M.2, Diggs A.2, Mildvan D.5
Introduction: Knowledge of and attitudes towards AIDS clinical trials (ACTs)are described among individuals from racial/ethnic minority backgrounds living with HIV/AIDS in New York City.
Methods: 287 persons living with HIV/AIDS (59.4% male) were recruited in 2004 from an AIDS service organization (47.6%) and community sampling. Participants completed a structured interview consisting primarily of previously validated measures. Data were analyzed using univariate and bivariate statistics.
Results: Participants were primarily from racial/ethnic minority backgrounds (African-American, 55.7%; Latino, 33.7%; White, 2.2%, other, 8.4%). The majority (95.8%) received Medicaid, and all reported being linked to a primary care provider. Most (73.2%) were receiving antiretroviral medications. Health concerns were common as reported on a standard measure (the SF-12), with 65.0% below the national average in physical health, and 66.8% on mental health. Knowledge of ACTs was poor ( = 53% correct). A third reported previous screening for ACTs. The most common barriers were concerns about the effectiveness of new treatments (62.5%) and side effects (61.6%). Regarding facilitating participation, altruism was the most commonly endorsed factor (85.3%). However, mistrust of scientists conducting ACTs was substantial (65.7%). There were few differences between racial/ethnic groups.
Conclusions: Despite a lack of accurate information about ACTs, the majority expressed substantial willingness to enroll in trials. Social relationships (health care provider, CBO, friends/family) are critical in leading to enrollment. ACT participation may be facilitated by an emphasis on altruism. Yet, ambivalence is suggested, as participants report significant mistrust of ACT scientists, which may be grounded in a history of scientific malpractice with communities of color in the U.S.
The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
MoPe11.1C05
Suggested Citation
"NakagawaA., et al.
AIDS Clinical Trials and Urban HIV+ Individuals from Racial/ethnic Minority Backgrounds: Knowledge, Attitudes, Barriers, and Facilitators.
Poster Exhibition:
The 3rd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
MoPe11.1C05"
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