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Abstract
Infection with human immunodeficiency virus and intestinal parasites in tuberculosis patients and the clinical manifestations of tuberculosis in HIV infected and uninfected patients in Gondar, Ethiopia
Kassu A.1, Ayele B.2, Diro E.2, Mekonnen F.2, Mengistu G.3, Ketema D.2, Moges F.2, Aseffa A.4, Wondmikun Y.2, Ota F.1
Introduction: Tuberculosis remains a major public health problem globally. Its high prevalence in sub Saharan Africa has been suggested to be associated with HIV pandemic among others. In Ethiopia, the prevalence of TB, HIV and intestinal parasitoses is very high. Yet information regarding their interaction is very scarce. This study was aimed at assessing the magnitude of HIV infection and intestinal parasitoses in TB patients and to describe its clinical manifestations in HIV infected and uninfected adult Ethiopians.
Methods: In a hospital based cross-sectional study, TB was diagnosed by combination of clinical, bacteriological, radiological and histological criteria. Intestinal parasites were detected by stool microscopy and serostatus for HIV infection was checked by an enzyme linked immunosorbent assay.
Results: Two hundred fifty seven TB patients were included in the study out of which 59.1% (152/257) were females. The total seroprevalence of HIV in the study population was 52.1% (134/257). The highest TB and HIV co-infection was found in the age group 25-44 years. No significant association was found between sputum smear positivity and HIV serostatus. Pulmonary TB and extrapulmonary TB were diagnosed in 51.8% and 48.2% of the patients respectively. No significant difference was observed in the clinical presentation between HIV positive and HIV negative tuberculosis patients. Forty point nine percent of the patients (105/257) were found to be infected with one or more species of intestinal protozoa or helminths. Strongyloides stercoralis showed a strong association with HIV seropositivity (X2=18.8, df=1, P<0.001).
Conclusions: The prevalence of intestinal parasitoses and HIV was very high in TB patients. This indicates an increased morbidity and highlights the importance of continued HIV sero-surveillance, stool analysis and treatment of intestinal parasites in patients with TB. Incorporating all TB patients in voluntary counseling and testing for HIV is recommended as a possible point of intervention.
The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
TuPe7.1C01
Suggested Citation
"KassuA., et al.
Infection with human immunodeficiency virus and intestinal parasites in tuberculosis patients and the clinical manifestations of tuberculosis in HIV infected and uninfected patients in Gondar, Ethiopia.
Poster Exhibition:
The 3rd IAS Conference on HIV Pathogenesis and Treatment:
Abstract no.
TuPe7.1C01"
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