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Abstract
Hepatitis C epidemiology and genotype distribution among HIV co-infected patients in Brazil
Mendes-Correa M.C.1, Cavalheiro N.2, Melo C.2, Barone A.A.2, Gianini R.J.3
Objectives: Evaluate the degree of exposure to different risk factors associated to HCV transmission and its genotypic distribution in a group of co-infected patients.
Methods: A case-control study was realized involving 235 HIV infected patients .118 tested positive for HCV and were included as cases, and 117 tested negative for HCV and were included as controls. Information was collected through a questionnaire. We initially conducted a multivariate analysis to determine the risk factors associated with co-infection ,which were: age > of 30 ,use of intravenous drugs, use of inhaled illicit drugs , anal intercourse, a sexual partner with a history of liver disease or a history of blood transfusions or a history of intravenous drug use. We then calculated to how many of these factors each patients, case or control, had been exposed to throughout their lives. For this analysis we also included history variables: blood transfusion, surgery, acupuncture, body piercing,blood handling,and hospitalization. 105 patients from the case group realized HCV genotyping through sequencing of the 5’NCR region of HCV.We tested the association of the variables related to hepatitis C transmission and the genotypes found. The Chi-square or Fischer association tests were used when the variable was categorical. The Kruskal-Wallis test was used when the variable was quantitative. Logistical regression was used for multivariable analysis.
Results: Co-infected patients presented a tendency for greater association with different risk factors than the control group patients. Genotype 1 was observed in 70 (66.6%) patients, type 3 in 25 (23.8%) and type 2 in 3 (2.8%). Genotype was undetermined in 7 (6.6%) patients. After the association tests, we observed that genotype 3 presented a strong association with IDU (OR=9.11; 95% CI, 1.06-204.73).
Conclusions: 1) multiple exposure to different risk factors associated to HCV transmission is common in HIV infected patients, but it is even more frequent in co-infected patients;
2) an association of genotype 3 with IDU was observed.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB208
Suggested Citation
"Mendes-CorreaM.C., et al.
Hepatitis C epidemiology and genotype distribution among HIV co-infected patients in Brazil.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB208"
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