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Abstract
Patients´ satisfaction with a salvage therapy based on enfuvirtide as part of a NRTI-sparing regimen - Telan study
Ribera E.1, Cervantes M.2, Domingo P.3, Fuster M.3, Pedrol E.4, González A.5, Cucurull J.6, Vega S.7, Force L.8, Delegido A.9
Objectives: The subcutaneous, self-administration of the fusion inhibitor enfuvirtide (ENF) in nucleoside reverse transcriptase inhibitor (NRTI)-sparing regimens should not be associated with a decrease in patients´ quality of life. This study assessed the impact of this rescue therapy on patients´ satisfaction.
Methods: This Catalonian cross-sectional study included HIV-infected adults under treatment with NRTI-sparing regimen containing ENF for at least 24 weeks. Patients´satisfaction with ENF was assessed with the MOSH-VIH questionnare. The subcutaneous administration was assessed by the Injection Site survey questionnaire. Frequency distributions and descriptive analysis were used, for the qualitative and quantitative variables and Parametric Mcnemar and T-Tests to compare data between treatment initation and the study visit.
Results: A total of 28 patients, mean age 44 years, were included. 92,9% started the treatment due to virologic failure. Mean±SD viral load at the beginning of ENF were 137.465±23042 cop/ml. Globally 65,4% reported that they felt “better” or “a lot better”. 67,9% of the patients, assessed their daily activities as "not at all" or "a little" limited by ENF self-injection. 67,6% of the patients found the injections "very easy" or "easy" to self administer. 86% of patients reported they never forgot to take the medication. There was a significant increase in the mean CD4 cell count (228±178 vs 364±241; p<0,005) and in the percentage of patients that reached undetectable viral load (3,6% vs 64,3%; p<0,001) between ENF initiation and the study visit.
Conclusions: These findings indicate that the addition of self-injected ENF to an NRTI-sparing regimen was not associated with a decrease in patients´ quality of life and showed little impact on their daily living. Patients´ satisfaction with ENF was high and the majority showed adherence to the treatment. ENF can be a good treatment choice in highly treated-experienced patients, where NRTI sparing may be necessary.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB265
Suggested Citation
"RiberaE., et al.
Patients´ satisfaction with a salvage therapy based on enfuvirtide as part of a NRTI-sparing regimen - Telan study.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB265"
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