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Abstract
Microbial profile of infection in pediatric HIV and its CD4+ correlation: case control study
Gadkari R.1, Dhande L.1, Chande C.1, Ughade S.1, Warhadpande U.1
Objectives: 1. To find out relative frequency of various microbial infections in pediatric HIV positive patients as against HIV negative patients coming with infections. 2. To correlate CD4+ cell counts with microbial profile.
Methods: Hospital based case –control study. Sample size: 67 cases and 134 controls. Study population: Children between age 18 months to 12 years
• Case Definition:Children coming to pediatric OPD with 1) Any infection with clinical presentation fitting at least 2 WHO case definition criteria and found positive on HIV Testing or2) Known HIV patients with infection. Control definition: Children coming with clinical presentation fitting at least 2 WHO case definition criteria with infection, found negative on HIV Testing.
Microbial profile, HIV testing and CD4 count done in all cases.
Statistical analysis done using Chi Square Test
Results:
1) Relative frequencies of microbes in HIV positive Vs HIV negative group were found significantly different in bacterial, mycobacterial and fungal infections but not in viral infections. HIV positive patients had a higher relative frequency of parasitic infections when toxoplasmosis excluded.
2) Mycobacterial infections, Cryptosporidium, Microsporidium, and Candida albicans infection occurred at higher frequency in HIV positive patients.
3) Correlation of microbial profile with CD4 counts: There was no correlation of frequency of infection by a pathogen with grade of immunosuppression, based on CD4 counts in the pathogens studied which included candida albicans, cryptosporidium, microsporidium, HSV, EBV,CMV, Toxoplasma and tuberculosis.
Conclusions: In children of age 18 months to 12 years, there is significant difference in relative frequencies of infections caused by bacteria as a group, fungus(Candida albicans), mycobacteria and protozoa (cryptosporidium and microsporidium) in HIV positive Vs HIV negative children suspected of AIDS based on presence of atleast 2 WHO case definition criteria. 2. There was no correlation of frequency of infection by a pathogen with grade of immunosuppression.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB148
Suggested Citation
"GadkariR., et al.
Microbial profile of infection in pediatric HIV and its CD4+ correlation: case control study.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB148"
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