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Abstract
RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV-1-infected Japanese hemophiliacs
Ichimura H.1, Koizumi Y.2, Kageyama S.1, Fujiyama Y.2, Shioda T.3
Objectives: The relationships between host immune factors and HIV-1 disease progression are still in dispute. Unlike CCR5D32 that have been proved to delay disease progression of HIV-1, there still remain several factors whose effect on clinical course left unconfirmed. The aim of this study was to clarify the relationships.
Methods: Seven single-nucleotide polymorphisms (SNPs) out of previously reported factors, namely, RANTES promoter -28G/-403A, RANTES In1.1C, SDF-1 3’A, IL-4 promoter -589T and DC-SIGN promoter -139C/-336C, were chosen, and examined in Japanese HIV-1-infected hemophiliacs (n=102). The genotypes were examined by direct sequencing method, and the distribution of genotype and allelic frequencies were compared between two groups, slow-progressors (n=54) who didn’t develop AIDS more than 10 years after intravenous infection and others (progressors) (n=48).
Results: Allelic frequency of RANTES -28G was significantly higher in slow-progressors (0.185) than in progressors group (0.074) (P=0.023, OR=0.35, 95%C.I. [0.142, 0.880]). DC-SIGN promoter -139C appeared in progressors with significantly higher allelic frequency (0.333) than that of slow-progressors (0.204, P=0.040, OR=1.95, 95%C.I. [1.039, 3.677]). With RANTES -403A, RANTES In1.1C, SDF-1 3’A, IL-4 -589T and DC-SIGN -336C, no significant difference was observed in allelic frequencies between the two groups.
Conclusions: These results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
TUPEA053
Suggested Citation
"IchimuraH., et al.
RANTES -28G delays and DC-SIGN -139C enhances AIDS progression in HIV-1-infected Japanese hemophiliacs.
Poster exhibition:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
TUPEA053"
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