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Abstract
Higher type 1 interferon levels in plasma could support NK cells activity in asymptomatic HIV-2 than in HIV-1 individuals
Nuvor S.V.1, Whittle H.1, Rowland-Jones S.1, Crozier S.1, Avieka A.1, Jaye A.1
Objectives: Interferon-a/b/g, IL-12, IL-15 and IL-18 are found to contribute to the development, maturation, differentiation and function of NK cells. We have observed higher function of NK cells in asymptomatic HIV-2 than HIV-1 infected subjects. In this study, we therefore compare levels of these cytokines in plasma of subjects that could possibly support NK cells function.
Methods: Thirty (30) subjects each of CD4+ T cells >500, 200-500 and <200 cells/ul groups in HIV-1 and HIV-2; also in 50 HIV uninfected donors were assayed by ELISA or CBA assay. Data were analysed by linear regression model using HIV status and CD4 categories as predictors
Results: IFN-a and IFN-b were higher in HIV-2 than HIV-1 subjects at high (p=0.001), medium (p<0.001) CD4+ T cells counts respectively and HIV uninfected control (p=0.001). IFN-a was lower at low CD4+ T cell counts (p=0.001) in HIV-2 with similar levels in HIV-1 subjects. IFN-g was higher in HIV-2 at low than high CD4+ T cell counts (p=0.002) and HIV uninfected control (p=0.001) with similar levels in HIV-1 subjects. IL-18, IL-12p70 and IL-15 were higher in HIV-2 at low than medium CD4+ T cell counts (p=0.001, p=0.047, p<0.001) respectively but only IL-18 in HIV-1 subjects (p=0.001). IL-15 was higher in HIV-2 at low CD4+ T cell counts than HIV-1 (p=0.031) and HIV uninfected control (p<0.001). IL-18 was higher in HIV-2 than in HIV-1 at low CD4+ T cells (p=0.014) and in both infections at all CD4+ T cell counts than in HIV uninfected control (p<0.05) except HIV-2 at high CD4+ T cell counts.
Conclusions: The levels and coordinated activity of cytokines may be important in activation of NK cells in early HIV infection. However, IFN-a might play a major role in NK cells function in HIV-2 infection that may contribute to prolong asymptomatic condition.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
MOPEA016
Suggested Citation
"NuvorS.V., et al.
Higher type 1 interferon levels in plasma could support NK cells activity in asymptomatic HIV-2 than in HIV-1 individuals.
Poster exhibition:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
MOPEA016"
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