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Abstract
Clinical-immunological features of HIV-infection in children of Uzbekistan
Subkhanova N.1, Kamilov A.I.1
Objectives: To study clinical,epidemiological and immunological peculiarites as well as cytokine status in children with perinatal HIV-infection and to improve the methods of treatment of disease
Methods: Clinical, biochemical, bacteriological, serological, immunological, statistic. 47 children, aged from 1 month to 8 years with diagnosis of HIV-infection.
Results: Characteristic features of perinatal HIV-infection in children is different manifestation of clinical signs: diarrheal syndrome (90%) of viral-bacterial etiology in perinatal infection. The percent of perinatal transmission of HIV-infection accounted for 32,4% before onset of antiretroviral therapy in Uzbekistan.In HIV-infection there are noted deep disorders in decrease of the total quantity of T-lymphocytes- 26,29%, T-helper (CD4)- 19,64% subpopulations and natural killers (CD16)-48,57%, as well as increase in immunoglobulins Ig G-1268,5 mg% and Ig M-212,86 mg%, FAN-24,86 mg% (p<0,01)suppression,gradual progressing and more marked in perinatal infection in children, that is consideredas criteria for assessment of disease severety. In children infected with HIV expressed as deep suppression of IFN-gamma production-7,31pg/ml associated with high indicators of IL-4-60,59pg/ml(p<0,01).Viferon in the complex therapy eliminated changes in the clinlcal, bichemical parameters, in humoral, cellular and cytokine status induced by adverse effect of antiretroviral therapy in children with perinatal HIV-infection.
Conclusions: The percent of perinatal transmission of HIV-infection accounted for 32,4% in Uzbekistan. It is advisableto include viferon rectally into the complex treatment of HIV-infection in children.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB035
Suggested Citation
"SubkhanovaN., et al.
Clinical-immunological features of HIV-infection in children of Uzbekistan
.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB035"
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