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Abstract
The relationship between weight and CD4 counts in HIV disease
Kizito W.1
Objectives: To determine the relationship between weight and CD4 counts in HIV disease prior to initiating HAART.
Methods: Hypotheses: The weight of HIV-infected adults is not related to absolute CD4 counts prior to initiating HAART.
Background: CD4 assays are an important step in determining when to initiate HAART in HIV-infected individuals, in resource-poor settings however these tests may not be readily available.
Methods: This was a retrospective record review of patients on HAART. A cohort of 1134 Ugandan adults on HAART were evaluated and in a systematic way their baseline CD4 absolute counts and weight were taken just before starting them on HAART. The subjects were diverse with respect to duration of HIV infection, level of immunologic deterioration, and route of HIV acquisition. They were 18 to 55 years of age and their mean weight and absolute CD4 count were 50.84 Kg and 92 respectively. We used Pearson’s correlation coefficient to look for a possible correlation between baseline weight and CD4 absolute counts.
Results: Pearson’s correlation coefficient suggested a positive correlation between mean weight and CD4 count, corr-coeff = 0.169. The model summary to relate CD4 to weight was; CD4 = 46.2 + 0.902 weight (p < 0.001) model r-value = 0.029 (p< 0.001)
Conclusions: From the above analysis we could clearly see weight was related to absolute CD4 counts in the adult population, it became clear that one could predict the CD4 count of a subject using weight as one of the parameters, and this could prove very important in resource poor settings where CD4 assays cannot be performed at times, so HAART could then be initiated with special emphasis to weight even in the absence of CD4 counts.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB285
Suggested Citation
" Kizito W.
The relationship between weight and CD4 counts in HIV disease.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB285"
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