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Abstract
Fifteen years of malignancies in HIV positive patients: increasing proportion of non HIV-associated tumors
Crippa F.1, Ceserani N.1, Ratti D.1, Cinque P.1, Bossolasco S.1, Castagna A.1, Fumagalli L.L.1, Galli L.1, Lazzarin A.2
Objectives: The advent of HAART has modified the natural history and the epidemiology of HIV-associated malignancies. However, non strictly HIV-related tumors are becoming increasingly frequent. We compared the frequencies of malignancies in the pre–HAART (1992-1996) and HAART (1997-2006) eras at our Institute.
Methods: Patients with malignancies who received care at our Institution from January 1st 1992 to December 31st 2006 were identified through our local database and retrospectively examined. Malignancies proportions and odds ratio with interval of confidence (IC95%) were calculated. Chi square test was used to compare proportions.
Results: From 1992 to 2006 we observed 543 cases of malignancy, 212 (average 42 cases/year) in the pre-HAART and 331 (average 33 cases/year) in the HAART timeframe. Non HIV-related malignancies were 84 (15.4% of the total), most of which (89%) were observed in the HAART period (p<0.001). The relative proportion of non HIV-related tumors in the HAART period (22.6%, n=75) was significantly higher than that observed in the pre-HAART period (4.2%, n=9); (p<0.001; OR= 6.61; 95%CI: 3.11-14.50). Histopathology of non HIV-related tumors in the pre-HAART period consisted of 3 adenocarcinomas, 3 squamous carcinomas and 3 of other types; in the HAART period 29 adenocarcinomas, 18 squamous carcinomas, 13 hepatocellular carcinomas and 15 other histological types were observed. The most frequently affected organs in the HAART period were lung (n=16), liver (n=13) and anus (n=8). Lymphomas (excluding Primary Central Nervous System Lymphomas) accounted for the 33% (70 cases) of all tumors in the pre HAART period and for the 42.9% (142 cases) in the HAART period (p= 0.027, OR= 0.656, 95%IC 0.6-0.94).
Conclusion: We documented a significant increase in the relative proportion of non-HIV related malignancies in the HAART period when compared to the pre-HAART period. A better understanding of the epidemiology of malignancies in HIV patients is crucial for screening, prevention and implement action.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
MOPEB083
Suggested Citation
"CrippaF., et al.
Fifteen years of malignancies in HIV positive patients: increasing proportion of non HIV-associated tumors.
Poster exhibition:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
MOPEB083"
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