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Abstract
Comparison study on the development of severe anemia as a side effect from two most commonly used HAART regimens in HIV/AIDS patients at Patna, India
Tejaswi D.1
Objectives: We had very little primary data on the occurrence of severe anemia as an adverse effect from the most commonly used first line HAART therapy in typical North Indian setting. Development of severe anemia as a complication from the two different but most commonly used first line HAART regimens in India were studied in the preset research. All the 108 adult male AIDS patients in the study were initially HAART naïve. 58 patients on Zidovudine (ZDV), Lamivudine (3TC) and Nevirapine (NVP) combination (Group 1) were compared with 50 patients on Stavudine (d4T), Lamivudine (3TC) and Nevirapine (NVP) combinations (Group 2) with regard to development of severe anemia as a complication of ART.
Methods: This research study was conducted between October 2005 and October 2006 at the HIV/AIDS clinic at Patna, India. 108 adult male HIV/AIDS patients between 18 to 45 years age group, ( all had CD4 cell count between 100-200, at the advent of HAART and the baseline Hemoglobin percent of all the selected patients were >85%). 58 patients (53.7%) were on were on ZDV/3TC/NVP combination while 50 patients (46.3%) were on d4T/3TC/NVP combination. Severe Anemia (Hb < 40%) as a major side effect was studied from these two combinations after 6 months of initiation of therapy. Viral load assessment was not done due to cost and time factor.
Results: At the end of 6 months of initiation of HAART, in Group 1, 18 patients developed severe anemia ( Hb< 40%) while in group 2, only 04 patients had developed severe anemia.When the data was analyzed with Chi Square Significance Testing, the difference was found to be statistically significant. (p<0.001)
Conclusions: From this observational study, we found that severe anemia as a complication were more prevalent in Group 1 patients compared to the group 2 patients.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB329
Suggested Citation
" Tejaswi D.
Comparison study on the development of severe anemia as a side effect from two most commonly used HAART regimens in HIV/AIDS patients at Patna, India.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB329"
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