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Abstract
To ascertain prokinectic CD4 levels associated with the most prevalent opportunistic infectious diagnoses and causes of morbidity & moratality among HIV patients seen at a sub-Saharan national reference hospital, Uganda
Wayengera, M.1, Eyumu J.2
Objectives: HIV-infected persons present in hospital at various CD4 strata, with differing Opportunistic diagnoses. Whereas some leave hospital alive, others succumb in course of that admission. We set out to ascertain prevalence of various opportunistic infectious diagnoses and causes of morbidity plus mortality among HIV patients in relation to the CD4 strata seen at the Mulago national reference hospital-Uganda,
Methods: Design: Prospective Study. 650 suspected HIV/AIDS patients who were seen between 2004 and 2005 at the Mulago National reference hospital-Uganda were reviewed, amongst whom 370 had under gone ELIZA tests for HIV status confirmation. These were later subjected to clinical assessment & finally a CD4 cell assay.
Results: 370(M:F=201:169, inpatient: outpatient=163:207, mean age 35.4 yrs [median37, mode38, std dev. 9.67, std err 0.5]) had a confirmed HIV diagnosis by ELIZA antibody tests, while 278 had HIV diagnoses by HIV 1 & 2 raid test strips. 2 however had been falsely diagnosed positive by rapid tests in relation to ELIZA. No follow up PCR was done. Of the 370 with a confirmed HIV diagnosis by ELIZA, 201 (54.3%) had an absolute CD4<200x106/L (48.8% on ARV versus 86.6% on septrin prophylaxis). Mortality among inpatients was 51 (31.3% [CD4<200x106/L=27%; CD4>200x106/L=4.3%]). Most prevalent OIs were: PTB (13%), Cryptococcal Meningitis/CCM (8.6%), Muco-cutaneous Candidaisis (5.9%) and gastroenteritis (5.7%), with Mortalities mainly due to CCM (28.3%), Dess.TB (13%), and PCP (13%).
Conclusions: Our results indicate that a CD4<200x106/L, Cryptococcal meningitis and Tuberculosis are highly associated with morbidity and mortality among HIV patients in this setting, and more efforts need be put in place to avail ARVs to them , as well as manage these OIs.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
CDB141
Suggested Citation
"Wayengera, et al.
To ascertain prokinectic CD4 levels associated with the most prevalent opportunistic infectious diagnoses and causes of morbidity & moratality among HIV patients seen at a sub-Saharan national reference hospital, Uganda.
:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
CDB141"
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