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Abstract
HIV and malaria co-infection in pregnancy: a comparative study of incidence and determinant
Udah F.1, Nwajei F.2
Objectives: Determining the effect of HIV-1 infection status on prevalence and intensity of malaria parasitaemia among pregnant Nigerians. Our present sensitivity of the human immune response to malaria and HIV lead us to anticipate that either infection might influence the clinical track of the other.
Methods: A cross-sectional study involving 105 pregnant HIV-1 positive ARV naïve and 199 pregnant HIV-1 negative consecutive Nigerians. Analysis of HIV infection was made using either a licensed double ELISA. Blood was collected at booking after obtaining consent for malaria parasite, CD4 count and viral load assay. Thin blood films were stained with leishman’s stain and a differential count was carried out on 100 cells. Thick blood films were Giemsa stained and examined for malaria parasite by using a x 100-oil immersion lens and x 7 eyepiece. One hundred fields were examined before a slide was declared negative. The result was analysed using SPSS statistical software.
Results: The prevalence of malaria parasitaemia in HIV-1 positives was 16.9% compared to 19.6% (p=0.59), with a mean parasite density of 1212.3 ± 1409.0ml-1 among HIV positive and 528.7±77.0ml-1 in HIV negative (p=0.08). further analysis showed no correlations between the CD4 counts, viral loads and stage of disease and presence or absence of malaria parasitaemia.
Conclusions: The result of this study shows that HIV-1 infection does not seem to affect the prevalence and density of malaria parasite in pregnant women. However a larger sample or size is required to confirm findings.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
MOPEA098
Suggested Citation
"UdahF., et al.
HIV and malaria co-infection in pregnancy: a comparative study of incidence and determinant.
Poster exhibition:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
MOPEA098"
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