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Abstract
The genetic variability of CYP2B6 polymorphisms in four Southern Chinese populations
He M.-L.1, Dong Q.1, Tan Y.1, Kung H.-f.1, Lee S.S.1
Objectives: To investigate the genetic variability of CYP2B6 polymorphisms in four Southern Chinese populations and its comparison with Caucasian, Hispanic, African, and other Asian populations reported in the literature.
Methods: Using discrimination real-time PCR and direct sequencing, we determined the CYP2B6 polymorphisms 64C>T and 516G>T in three Yunnan minority ethnic groups Lahu (n=108), Wa (n=101), Bulang (n=99), and Hong Kong Chinese population (n=199), all of which were resident in Southern China.
Results: The frequencies of 64C>T in four Southern Chinese groups were Lahu 6.5%, Wa 6.4%, Bulang 11.6%, and Hong Kong 11.6%; frequencies of 516G>T were Lahu 31.5%, Wa 40.1%, Bulang 29.3%, and Hong Kong 35.9%. The 516TT genotype was significantly higher in Hong Kong population than Lahu and Bulang (p<0.01). The 516G>T frequency was significantly higher in Southern Chinese, as compared to other Asian and Caucasian populations (p<0.05). No difference was found between Chinese-yunnan population and most Hispanic populations and African populations (p>0.05).
Conclusions: This is the first study which investigates CYP2B6 polymorphism in Southern Chinese populations. The frequency of 516G>T, an important determinant in the metabolism of antiretroviral compounds for HIV/AIDS and drugs in other clinical conditions, is similar to Hispanics and most African populations but higher than other Asian and Caucasian populations. This finding may help to improve individualization of drug therapy in the South China populations.
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
Abstract no.
MOPEA068
Suggested Citation
"HeM.-L., et al.
The genetic variability of CYP2B6 polymorphisms in four Southern Chinese populations.
Poster exhibition:
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention:
Abstract no.
MOPEA068"
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