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Abstract
MULTIPLE DRUG RESCUE THERAPY (MDRT) WITH AND WITHOUT LOPINAVIR/R (LPV/R)
HARRIS M, YIP B, HOGG R, HARRIGAN R, MONTESSORI V, O'SHAUGHNESSY M, MONTANER J
Objectives: To determine the impact of the availability of LPV/r on the antiviral response to MDRT regimens among heavily pretreated patients.
Methods: Patients who failed several prior antiretroviral (ARV) regimens started MDRT including at least 5 ARV drugs between June 1999 and December 1999 (immediately prior to the availability of LPV/r in B.C., pre-LPV/r cohort), or MDRT including LPV/r (counted as 2 drugs) between January 2000 and July 2000 (LPV/r cohort). Virologic response was defined as plasma viral load (pVL) <400 copies/mL on at least 2 consecutive visits.
Results: Participants in both the pre-LPV/r cohort (N=54) and the LPV/r cohort (N=71) received a median of 6 ARV drugs (IQR 5-6). Median baseline (pre-MDRT) pVL was 36K copies/mL (IQR 0.7-201K) and 93K copies/mL (IQR 5.2-343K) for the pre-LPV/r and LPV/r cohorts, respectively. The two cohorts had prior median ARV exposure of 41 months (IQR19-53) and 33 months (IQR 20-52), respectively. Median followup times are 16 months and 9 months for the pre-LPV/r and the LPV/r cohorts, respectively. Based on an intent to treat (ITT) analysis, 65% of pre-LPV/r cohort participants reached pVL <400 copies/mL consecutively at least twice and 56% had pVL <400 copies/mL consecutively at least three times. In the LPV/r cohort, 68% and 59% had pVL <400 copies/mL consecutively at least twice and three times, respectively. During week 25-35, 48% of pre-LPV/r cohort participants and 59% of LPV/r cohort participants had pVL <400 c/mL on ITT analyses. Genotypic resistance analyses are pending to help characterize predictors of response.
Conclusions: Our preliminary results demonstrate that access to LPV/r was associated with a more favourable virologic response to MDRT among heavily pretreated patients.
The 1st. IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
114
Suggested Citation
"HARRISM, et al.
MULTIPLE DRUG RESCUE THERAPY (MDRT) WITH AND WITHOUT LOPINAVIR/R (LPV/R).
Oral Presentation:
The 1st. IAS Conference on HIV Pathogenesis and Treatment
:
Abstract no.
114"
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