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Abstract
IMPACT OF TREATMENT INTERRUPTION ON PLASMA VIRAL LOAD, CD4 COUNT AND VIRTUAL PHENOTYPES_ (VIRCO) IN HIV PATIENTS WHO FAILED MULTIPLE COURSES OF ANTIRETROVIRAL THERAPY.
TESIOROWSKI A, HARRIS M, HARRIGAN R, O'SHAUGHNESSY M, MONTANER J
Objectives: To assess changes in plasma viral load (VL), CD4 percentage, absolute CD4 count and Virtual Phenotypes? following interruption of therapy in a cohort of heavily pretreated individuals. Methods: Observational study. Results: There were 31 HIV infected, treatment experienced patients at median age 38 (range 28-58) who stopped their treatment because of the virological failure. They were off therapy for median 24 weeks (range 5-111). Median increase in plasma viral load was 25,064 copies/ml per month (range 939 - 318,389 copies/ml). Median drop of absolute CD4 count was 27.1 cells/mm3 per month (range 0 -145,7). Median decrease in CD4 fraction was 1.0% per month (range 0 - 4,0). Of note, these changes were not linear on time. Viral isolates reverted to sensitive type in 14 of 22 patients (63%). Sustained resistance in 8 patients was mainly to NNRTI (5 of 10) and AZT (5 of 15) but not so to other nucleosides and the PIs. After initiation of MDRT plasma VL <50 copies/ml was reached by 8/14 patients whose viral isolates switched to sensitive type in median 14 week (range 8-32) and by 3/8 patients whose viral isolates remained resistant in median 8 week (range 8-12). Plasma viral load rebound occurred in 4 patients in the sensitive type group in median 16 week (range 12-20) and in 2 patients in the resistant type group in median 10 week (range 8-12). Conclusions: Long term antiretroviral treatment interruption causes significant increase of plasma viral load and drop of CD4 count. Resistance profiles measured by virtual phenotype alter considerably after treatment interruption. Most of the patients lost their resistance to DD drugs, 3TC, abacavir and PI. There is a tendency to sustain resistance to NNRTI and AZT.
The 1st. IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
111
Suggested Citation
"TESIOROWSKIA, et al.
IMPACT OF TREATMENT INTERRUPTION ON PLASMA VIRAL LOAD, CD4 COUNT AND VIRTUAL PHENOTYPES_ (VIRCO) IN HIV PATIENTS WHO FAILED MULTIPLE COURSES OF ANTIRETROVIRAL THERAPY..
Oral Presentation:
The 1st. IAS Conference on HIV Pathogenesis and Treatment
:
Abstract no.
111"
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