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Abstract
HYDROXYUREA THERAPY SPARES THE NAIVE T CELL COMPARTMENT IN PATIENTS TREATED WITH ANTIRETROVIRAL DRUGS: THE 3D STUDY
OGORMAN M, ALATRAKCHI N, BELSEY E, LANDAY A, KATLAMA C, MURPHY R, AUTRAN B
Background:The effects of HU on the immune system of HIV patients have not been elucidated. The objective was to evaluate immune changes in CD4 and CD8 T cells in 3D, a multicenter, randomized, placebo-controlled 48 week trial of efavirenz, stavudine and ddI plus HU or placebo (PBO).
Method:HU (600 mg bid) was added to regimen at week 8. 41 patients naive of antiretroviral drugs, CD4 counts =100 cell/ul, HIV RNA =500 c/ml were eligible for this substudy. 10 of 21 patients in the HU group and 11 of 20 in the PBO group remained on drug and had immune work-up at week 48. Flow cytometry was performed using standard methodology.
Results:By week 48 there was a non-significant (sig.) decrease in CD4+ counts in the HU group however there was a sig. increase in naïve (CD62L+CD45RA+) CD4 T cells (+76 p=.02) contrasted with a sig. increase in both total CD4 T cells and (+297, p=0.027) and naïve CD4 T cells (112, p=.004) in the PBO group. There was a sig. increase in %CD4 T-cells and %CD4-naïve T cells in both groups. CD8 T cell counts did not change sig. in either group:naïve CD8 T cells did not change sig. in the HU group but increased in the PBO group (+88, p=.008). The %CD8+ T cells decreased (-8% and -3%, both p<0.05) and %-naïve CD8 T cells increased (+15% and +11%, both p<0.05) in HU and PBO respectively. Sig. decreases in the % activated CD4 (38+DR+) and activated CD8 T cells (CD38+) were observed in both groups whereas counts decreased sig. only in HU. Finally the % and absolute CD4 and CD8 T cells expressing Fas/CD95 decreased sig. only in the HU group.
Conclusion.The increase in proportion and number of naive CD4 T cells without a sig.increase in the absolute CD4 count indicates a relative decrease in the memory CD4 T cell compartment in HU treated patients. This finding with the decrease in activated T cells, suggests HU selectively affects activated-memory CD4 T cells while sparing the naïve T cell compartment that provides the host’s reservoir for immune defense.
The 1st. IAS Conference on HIV Pathogenesis and Treatment
Abstract no.
107
Suggested Citation
"OGORMANM, et al.
HYDROXYUREA THERAPY SPARES THE NAIVE T CELL COMPARTMENT IN PATIENTS TREATED WITH ANTIRETROVIRAL DRUGS: THE 3D STUDY.
Oral Presentation:
The 1st. IAS Conference on HIV Pathogenesis and Treatment
:
Abstract no.
107"
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